Comparison of polyethylene glycol vs sodium picosulphate vs sodium biphosphonate by efficacy in bowel cleansing and patients' tolerability: a randomised trial.

Autor: Heetun Z; Department of Gastroenterology and Hepatology, St Luke's Hospital, Kilkenny, Ireland. heetunz@gmail.com., Crowley R; Department of Gastroenterology and Hepatology, St Luke's Hospital, Kilkenny, Ireland., Zeb F; Department of Gastroenterology and Hepatology, St Luke's Hospital, Kilkenny, Ireland., Kearns D; Department of Gastroenterology and Hepatology, St Luke's Hospital, Kilkenny, Ireland., Brennan MH; Department of Gastroenterology and Hepatology, St Luke's Hospital, Kilkenny, Ireland., O'Connor C; Department of Gastroenterology and Hepatology, St Luke's Hospital, Kilkenny, Ireland., Courtney G; Department of Gastroenterology and Hepatology, St Luke's Hospital, Kilkenny, Ireland., Aftab AR; Department of Gastroenterology and Hepatology, St Luke's Hospital, Kilkenny, Ireland.
Jazyk: angličtina
Zdroj: Irish journal of medical science [Ir J Med Sci] 2016 Aug; Vol. 185 (3), pp. 629-633. Date of Electronic Publication: 2015 May 30.
DOI: 10.1007/s11845-015-1320-7
Abstrakt: Introduction: Adequate bowel preparation is necessary for a complete colonoscopy. Polyethylene glycol-electrolyte oral solution (PEG-EOS), sodium picosulphate (SS) and sodium biphosphonate (SP) are the three most commonly used purgative agents. We aimed to determine their efficacy and tolerability compared to each other in a randomised study.
Methods: 313 patients were randomly assigned to receive either PEG-EOS, SS or SP. Patients completed a tolerability score pre-colonoscopy. A cleanliness score was used to document adequacy of bowel preparation. A separate group of patients completed taste scores for the three cathartic agents before and after addition of flavour.
Results: PEG-EOS was the worst-tolerated regimen but achieved the highest rates of right colonic cleansing and the lowest rate of incomplete colonoscopies. There were no statistical differences in the rates of rectosigmoid and mid-gut cleansing among the three agents. SS was by far the preferred purgative in the taste assessment study. Addition of flavour increased significantly taste scores for PEG-EOS.
Conclusion: For adequate bowel cleansing PEG-EOS is the most effective but is the least tolerated and least preferred among patients. Addition of flavour increases significantly patients' acceptance of PEG-EOS.
Databáze: MEDLINE
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