A study of blood serotonin and serotonin transporter promoter variant (5-HTTLPR) polymorphism in Egyptian autistic children.
| Autor: | Meguid NA; Department of Research on Children with Special Needs, Medical Division National Research Centre, Cairo, Egypt., Gebril OH; Department of Research on Children with Special Needs, Medical Division National Research Centre, Cairo, Egypt., Khalil RO; Department of Research on Children with Special Needs, Medical Division National Research Centre, Cairo, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | Advanced biomedical research [Adv Biomed Res] 2015 May 11; Vol. 4, pp. 94. Date of Electronic Publication: 2015 May 11 (Print Publication: 2015). |
| DOI: | 10.4103/2277-9175.156658 |
| Abstrakt: | Background: Autism spectrum disorder (ASD) is a complex, heterogeneous neurodevelopmental disorder with onset during early childhood. Most studies have reported an elevation in platelet serotonin in persons with autism. The serotonin (5-hydroxytryptamine; 5-HT) transporter in the brain uptakes 5-HT from extracellular spaces. It is also present in platelets, where it takes up 5-HT from plasma. Polymorphisms in serotonin transporter gene (SLC6A4) were frequently studied in many neuropsychiatric disorders. Materials and Methods: We have measured the plasma 5-HT levels in 20 autistic male children and 20 control male children by the enzyme-linked immunosorbent assay (ELISA) method. In addition, the SLC6A4 promoter region (5-HTTLPR) insertion/deletion (I/D) polymorphism was studied, using whole genomic DNA. Results: Plasma serotonin was significantly low in autistic children compared to control (P = 0.001), although correlation to severity of autism was not significant. The frequency of short (S) allele in autism cases was 10% and in the control group it was absent. Conclusion: Our study demonstrated an increased prevalence of 5-HTTLPR S allele in autism subjects. Significantly decreased plasma serotonin was detected in autism subjects, with no significant relationship between 5-HTTLPR genotype and plasma 5-HT being evident. |
| Databáze: | MEDLINE |
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