Feasibility of immunochemical faecal occult blood testing for colorectal cancer screening in Bulgaria.
| Autor: | Tsvetanova Dimova R; Department of the Health Management, Health Economics and Primary Care, Faculty of Public Health, Medical University of Plovdiv, 15a V. Aprilov Blvd, Plovdiv, Bulgaria., Dimitrova Dimitrova D, Angelova Levterova B, Stoyanov Dimov R, Atanasova Semerdjieva M, Frantova Tarnovska M, Gencheva Stoyanova R |
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| Jazyk: | angličtina |
| Zdroj: | Journal of B.U.ON. : official journal of the Balkan Union of Oncology [J BUON] 2015 Mar-Apr; Vol. 20 (2), pp. 413-20. |
| Abstrakt: | Purpose: Colorectal carcinoma (CRC) is the second most common cancer in Europe. Screening guidelines recommend a range of screening options that include faecal occult blood tests (FOBTs). The efficacy of FOBT-based CRC screening is dependent on the participation rate, thus emphasizing the importance of the latter. This study aimed at analysing the feasibility of CRC screening with immunochemical FOBT (iFOBT). Methods: A cross-sectional study of 600 asymptomatic persons at average risk, aged ≥45years from urban and rural municipalities was performed. An educational brochure, iFOBT kit with translated colored leaflet, informed consent form and questionnaire were administered to participants by 30 general practitioners. Faecal samples were analysed for occult blood using point-of-care rapid iFOBT (cut off 10 ng(GPs)Hb/ml) by the patients themselves at home. The questionnaire aimed to establish if they encountered difficulties in self-testing and self-analysing. Direct and indirect measures of test feasibility were used difficulties for reported study participation rate. Results: The participation rate was 78.8% (473 participants). Patients < 65 years (x² =70.8, Р<0.001), those with lower education level (x² =82.1, p<0.001), and patients living in villages (x² =4.3, p<0.05) reported difficulties more frequently and they needed help for self-testing by iFOBT. Positive test was found in 8.5% of all participants. Of them 19 persons (48.7%) had haemorrhoids, 8 (20.0%) benign neoplasms, and 3 (7.5%) had CRC. Conclusions: CRC screening study by means of iFOBT as a point-of-care test proved to be feasible, since a high participation rate was obtained. |
| Databáze: | MEDLINE |
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