Serum cystatin C - marker of inflammation and cardiovascular morbidity in chronic kidney disease stages 1-4.

Autor:	Muslimovic A; Clinic of Nephrology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina., Tulumovic D; Department of Nephrology, Dialysis and Kidney Transplantation, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina., Hasanspahic S; Clinic of Nephrology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina., Hamzic-Mehmedbasic A; Clinic of Nephrology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina., Temimovi R; Institute for Occupational Medicine of Canton Sarajevo, Sarajevo, Bosnia and Herzegovina.
Jazyk:	angličtina
Zdroj:	Materia socio-medica [Mater Sociomed] 2015 Apr; Vol. 27 (2), pp. 75-8. Date of Electronic Publication: 2015 Apr 05.
DOI:	10.5455/msm.2015.27.75-78
Abstrakt:	Aim: The aim of the research was to compare the relationship between inflammatory biomarkers and procoagulants with kidney function assessed by using cystatin C, serum creatinine, and eGFR and determine the sensitivity of cystatin C, serum creatinine and eGFR to total cardiovascular morbidity in patients with CKD stages 1-4. Methods: The research included 120 patients older than 18 years with CKD stages 1-4 monitored over a period of 24 months. Results: Serum cystatin C correlates with fibrinogen (p<0.01), serum albumin (p<0.01), D-dimer (p<0.05), antithrombin III (p<0.01) strongly in relation to the evaluation of kidney function based on serum creatinine and eGFR. By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p<0.05). Conclusion: Serum cystatin C is more strongly correlated with some biomarkers (fibrinogen, serum albumin, D-dimer, antithrombin III), while simultaneously showing a stronger sensitivity in relation to total cardiovascular morbidity compared with the assessment of kidney function based on serum creatinine and eGFR.
Databáze:	MEDLINE
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