Review: Puberty as a time of remodeling the adult response to ovarian hormones.

Autor: Blaustein JD; Department of Psychological and Brain Sciences, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003-9271, USA. Electronic address: blaustein@cns.umass.edu., Ismail N; Department of Psychological and Brain Sciences, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003-9271, USA. Electronic address: Nafissa.Ismail@uottawa.ca., Holder MK; Department of Psychological and Brain Sciences, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003-9271, USA. Electronic address: mconklin@gsu.edu.
Jazyk: angličtina
Zdroj: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2016 Jun; Vol. 160, pp. 2-8. Date of Electronic Publication: 2015 May 21.
DOI: 10.1016/j.jsbmb.2015.05.007
Abstrakt: During pubertal development, an animal's response to stress changes and sexual differentiation of the brain and behavior continue. We discovered that particular stressors, such as shipping from suppliers or an immune challenge with lipopolysaccharide, during the prolonged pubertal period of female mice result in long-term changes in behavioral responsiveness of the brain to estradiol assessed in adulthood. All behaviors influenced by estradiol and/or progesterone that we have studied are compromised by a stressor during pubertal development. Depending on the behavior, immune challenge or shipping from suppliers during pubertal development decreases, eliminates, or even reverses the effects of estradiol. Shipping during this period causes changes in the number of estrogen receptor-immunoreactive cells in key brain areas suggesting one cellular mechanism for this remodeling of the brain's response to hormones. We suggest that particular adverse experiences in girls may cause long-term alterations in the brain's response to estradiol and/or progesterone via activation of the immune system. This in turn could lead to an alteration in any aspect of mental health that is influenced by estradiol.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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