| Autor: |
Travers BG; Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, WI, 53705, USA, btravers@wisc.edu., Bigler ED, Tromp do PM, Adluru N, Destiche D, Samsin D, Froehlich A, Prigge MD, Duffield TC, Lange N, Alexander AL, Lainhart JE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of autism and developmental disorders [J Autism Dev Disord] 2015 Sep; Vol. 45 (9), pp. 3030-40. |
| DOI: |
10.1007/s10803-015-2467-9 |
| Abstrakt: |
Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5-33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicted more severe autism symptoms. Fractional anisotropy of the brainstem's corticospinal tract predicted both grip strength and autism symptom severity and mediated the relationship between the two. These findings suggest that brainstem white matter may contribute to autism symptoms and grip strength in ASD. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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