Maternal obesity and development of the preterm newborn at 2 years.

Autor: van der Burg JW; Health and Life Sciences, Faculty of Earth and Life Sciences, VU University, Amsterdam, The Netherlands.; Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA., Allred EN; Neuroepidemiology Unit, Department of Neurology, Boston Children's Hospital, Harvard University, Boston, MA, USA., Kuban K; Division of Neurology, Department of Pediatrics, Boston Medical Center and Boston University, Boston, MA, USA., O'Shea TM; Department of Pediatrics, Wake Forest University, Winston-Salem, NC, USA., Dammann O; Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.; Neuroepidemiology Unit, Department of Neurology, Boston Children's Hospital, Harvard University, Boston, MA, USA.; Perinatal Epidemiology Unit, Hannover Medical School, Hannover, Germany., Leviton A; Neuroepidemiology Unit, Department of Neurology, Boston Children's Hospital, Harvard University, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2015 Sep; Vol. 104 (9), pp. 900-3. Date of Electronic Publication: 2015 May 29.
DOI: 10.1111/apa.13038
Abstrakt: Aim: To evaluate to what extent extremely preterm children (<28 weeks' gestational age) of overweight (BMI 25-29) or obese (BMI ≥30) women are at increased risk of adverse development at 2 years measured with the Bayley Scales of Infant Development II in a multicenter prospective cohort study.
Methods: Heights and prepregnancy weights of the mothers of 852 preterm born children were collected and included in multinomial logistic regression models.
Results: Compared to newborns born to mothers with normal BMIs, newborns of obese mothers, but not those of overweight mothers, were more likely to have Bayley Scales indices more than 3 standard deviations below the reference mean (mental: OR = 2.1; 95% CI: 1.3, 3.5) (motor: OR = 1.7; 95% CI: 1.1, 2.7). These associations were even more prominent in children who did not have the intermittent or sustained systemic inflammation profile previously shown to be associated with severely impaired development (mental: OR = 4.6; 95% CI: 1.6, 14) (motor: OR = 3.7; 95% CI: 1.5, 8.9).
Conclusion: Maternal obesity is associated with an increased risk of impaired offspring development. Some of this impaired development cannot be attributed to confounding due to immaturity, socio-economic correlates or neonatal systemic inflammation.
(©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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