Resting state signatures of domain and demand-specific working memory performance.

Autor: van Dam WO; Department of Psychology, University of South Carolina, USA., Decker SL; Department of Psychology, University of South Carolina, USA., Durbin JS; Department of Psychology, University of South Carolina, USA., Vendemia JM; Department of Psychology, University of South Carolina, USA., Desai RH; Department of Psychology, University of South Carolina, USA. Electronic address: rutvik@sc.edu.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2015 Sep; Vol. 118, pp. 174-82. Date of Electronic Publication: 2015 May 14.
DOI: 10.1016/j.neuroimage.2015.05.017
Abstrakt: Working memory (WM) is one of the key constructs in understanding higher-level cognition. We examined whether patterns of activity in the resting state of individual subjects are correlated with their off-line working and short-term memory capabilities. Participants completed a resting-state fMRI scan and off-line working and short-term memory (STM) tests with both verbal and visual materials. We calculated fractional amplitude of low frequency fluctuations (fALFF) from the resting state data, and also computed connectivity between seeds placed in frontal and parietal lobes. Correlating fALFF values with behavioral measures showed that the fALFF values in a widespread fronto-parietal network during rest were positively correlated with a combined memory measure. In addition, STM showed a significant correlation with fALFF within the right angular gyrus and left middle occipital gyrus, whereas WM was correlated with fALFF values within the right IPS and left dorsomedial cerebellar cortex. Furthermore, verbal and visuospatial memory capacities were associated with dissociable patterns of low-frequency fluctuations. Seed-based connectivity showed correlations with the verbal WM measure in the left hemisphere, and with the visual WM measure in the right hemisphere. These findings contribute to our understanding of how differences in spontaneous low-frequency fluctuations at rest are correlated with differences in cognitive performance.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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