Invariant natural killer T cells and their ligands: focus on multiple sclerosis.

Autor: O'Keeffe J; Department of Life and Physical Sciences, School of Science, Galway-Mayo Institute of Technology, Galway, Ireland., Podbielska M; Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, GA, USA.; Laboratory of Signalling Proteins, Ludwik-Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland., Hogan EL; Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, GA, USA.; Department of Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland.
Jazyk: angličtina
Zdroj: Immunology [Immunology] 2015 Aug; Vol. 145 (4), pp. 468-75. Date of Electronic Publication: 2015 Jun 25.
DOI: 10.1111/imm.12481
Abstrakt: Invariant natural killer T (iNKT) cells are an innate population of T cells identified by the expression of an invariant T-cell receptor and reactivity to lipid-based antigens complexed with CD1d. They account for a small percentage of lymphocytes, but are extremely potent and play central roles in immunity to infection, in some cancers, and in autoimmunity. The list of relevant stimulatory lipids and glycolipid antigens now includes a range of endogenous self-antigens including the myelin-derived acetylated galactosylceramides. Recent progress in studies to identify the nature of lipid recognition for iNKT cells in autoimmune diseases like multiple sclerosis is likely to foster the development of therapeutic strategies aimed at harnessing iNKT cell activity.
(© 2015 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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