| Autor: |
Jalbut MM; Tufts University School of Medicine, Boston, MA, United States., Sohani AR; Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Dal Cin P; Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA, United States., Hasserjian RP; Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Moran JA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Brunner AM; Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Fathi AT; Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. |
| Abstrakt: |
Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cytogenetic and subsequent FISH analyses revealed a constitutional 47,XXY karyotype. We also review and discuss relevant prior literature. |
