Formulating the Future Research Agenda for Postexposure Prophylaxis for HIV: Methodological Challenges and Potential Approaches.

Autor:	Siegfried N; Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa Department of Epidemiology and Biostatistics, University of California, San Francisco., Beanland RL; Department of HIV/AIDS, World Health Organization, Geneva, Switzerland., Ford N; Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa Department of HIV/AIDS, World Health Organization, Geneva, Switzerland., Mayer KH; The Fenway Institute, Fenway Health Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2015 Jun 01; Vol. 60 Suppl 3, pp. S205-11.
DOI:	10.1093/cid/civ139
Abstrakt:	Background: During a World Health Organization-convened Guideline Development Group meeting, recommendations for postexposure prophylaxis (PEP) for human immunodeficiency virus were made and research gaps identified. Methods: We used the PEP clinical management pathway and the Grading of Evidence, Assessment, Development and Evaluation (GRADE) system as a framework to formulate future research questions, describe the most feasible study design, and identify potential biases. Results: Three key study design formats were identified to address 12 research questions: (1) survey- and interview-driven research to identify barriers to access to PEP and related clinical care; (2) establishment of a global PEP registry to generate data to inform the choice of an optimal PEP drug regimen, record drug toxicities arising from specific PEP regimens, and track follow-up and linkage to care (including transition from PEP to preexposure prophylaxis); and (3) randomized controlled trials to determine the optimal adherence promotion strategies necessary for successful outcomes following PEP. Conclusions: Positioning key clinical and programmatic research questions within the GRADE framework facilitates the formulation of an evidence-based research agenda and future revisions of guidelines. (© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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