Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease.
| Autor: | LaFleur RL; Merck Animal Health, Inc., Elkhorn, Nebraska, USA., Callister SM; Gundersen Health System, La Crosse, Wisconsin, USA smcallis@gundersenhealth.org., Dant JC; Merck Animal Health, Inc., Elkhorn, Nebraska, USA., Wasmoen TL; Merck Animal Health, Inc., Elkhorn, Nebraska, USA., Jobe DA; Gundersen Health System, La Crosse, Wisconsin, USA., Lovrich SD; Gundersen Health System, La Crosse, Wisconsin, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2015 Jul; Vol. 22 (7), pp. 836-9. Date of Electronic Publication: 2015 May 13. |
| DOI: | 10.1128/CVI.00193-15 |
| Abstrakt: | Beagles received placebo or ospA- and ospB-negative Borrelia burgdorferi before a tick challenge. A total of 28 (41%) ticks and skin biopsy specimens from each control dog (n = 10) contained B. burgdorferi. In contrast, 12 (19%) ticks recovered from the vaccine recipients (n = 10) were infected (P = 0.0077), and 5 dogs yielded spirochetes from the skin biopsy specimens (P = 0.0325). In addition, 9 (90%) placebo recipients and 4 (40%) vaccine recipients developed joint abnormalities (P = 0.0573). Therefore, vaccination with the ospA- and ospB-negative spirochete provided significant protection against Lyme disease. (Copyright © 2015, American Society for Microbiology. All Rights Reserved.) |
| Databáze: | MEDLINE |
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