Sol-gel processing of novel bioactive Mg-containing silicate scaffolds for alveolar bone regeneration.
| Autor: | Goudouri OM; Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen, Germany., Vogel C; Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen, Germany., Grünewald A; Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen, Germany., Detsch R; Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen, Germany., Kontonasaki E; Department of Fixed Prosthodontics, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece., Boccaccini AR; Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen, Germany ouraniamenti-goudouri@uiowa.edu aldo.boccaccini@ww.uni-erlangen.de. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of biomaterials applications [J Biomater Appl] 2016 Jan; Vol. 30 (6), pp. 740-9. Date of Electronic Publication: 2015 May 12. |
| DOI: | 10.1177/0885328215584887 |
| Abstrakt: | Periodontal tissue regeneration is an important application area of biomaterials, given the large proportion of the population affected by periodontal diseases like periodontitis. The aim of this study was the synthesis of a novel porous bioceramic scaffold in the SiO2-CaO-MgO system with specific properties targeted for alveolar bone tissue regeneration using a modification of the traditional foam replica technique. Since bioceramic scaffolds are considered brittle, scaffolds were also coated with gelatin in order to increase their mechanical stability. Gelatin was chosen for its biocompatibility, biodegradability, low-cost, and low immunogenicity. However, gelatin degrades very fast in water solutions. For this reason, two different cross-linking agents were evaluated. Genipin, a non-toxic gardenia extract and the chemical compound 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) in combination with N-hydroxysuccinimide (NHS), which is also considered non-toxic. The results of the investigation indicated that all scaffolds presented an open, interconnected porosity and pores' sizes in the range of 300-600 μm, fast apatite-forming ability, biocompatibility, and suitable mechanical stability. (© The Author(s) 2015.) |
| Databáze: | MEDLINE |
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