Increased prefrontal cortex neurogranin enhances plasticity and extinction learning.

Autor:	Zhong L; Departments of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center, and., Brown J; Departments of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center, and., Kramer A; Departments of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center, and., Kaleka K; Departments of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center, and., Petersen A; Departments of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center, and., Krueger JN; Molecular & Behavioral Neuroscience Institute and., Florence M; Departments of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center, and., Muelbl MJ; Neuroscience Research Center, and Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin 53132., Battle M; Departments of Cell Biology, Neurobiology and Anatomy., Murphy GG; Molecular & Behavioral Neuroscience Institute and Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109., Olsen CM; Neuroscience Research Center, and Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin 53132., Gerges NZ; Departments of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center, and ngerges@mcw.edu.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2015 May 13; Vol. 35 (19), pp. 7503-8.
DOI:	10.1523/JNEUROSCI.0274-15.2015
Abstrakt:	Increasing plasticity in neurons of the prefrontal cortex (PFC) has been proposed as a possible therapeutic tool to enhance extinction, a process that is impaired in post-traumatic stress disorder, schizophrenia, and addiction. To test this hypothesis, we generated transgenic mice that overexpress neurogranin (a calmodulin-binding protein that facilitates long-term potentiation) in the PFC. Neurogranin overexpression in the PFC enhanced long-term potentiation and increased the rates of extinction learning of both fear conditioning and sucrose self-administration. Our results indicate that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks. Thus, neurogranin can provide a molecular link between enhanced plasticity and enhanced extinction. (Copyright © 2015 the authors 0270-6474/15/357503-06$15.00/0.)
Databáze:	MEDLINE
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