Femoral lipectomy increases postprandial lipemia in women.

Autor:	Hernandez TL; Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, College of Nursing, and., Bessesen DH; Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, Denver Health and Hospital Authority, Denver, Colorado; and., Cox-York KA; Department of Nutrition, Colorado State University, Fort Collins, Colorado., Erickson CB; Department of Medicine, Division of Geriatric Medicine., Law CK; Department of Dermatology, Cosmetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado;, Anderson MK; Department of Medicine, Division of Geriatric Medicine., Wang H; Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes., Jackman MR; Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes., Van Pelt RE; Department of Medicine, Division of Geriatric Medicine, rachael.vanpelt@ucdenver.edu.
Jazyk:	angličtina
Zdroj:	American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2015 Jul 01; Vol. 309 (1), pp. E63-71. Date of Electronic Publication: 2015 May 12.
DOI:	10.1152/ajpendo.00080.2015
Abstrakt:	Femoral subcutaneous adipose tissue (SAT) appears to be cardioprotective compared with abdominal SAT, possibly through better triglyceride (TG) sequestration. We hypothesized that removal of femoral SAT would increase postprandial TG through a reduction in dietary fatty acid (FA) storage. Normal-weight (means ± SD; BMI 23.9 ± 2.6 kg/m(2)) women (n = 29; age 45 ± 6 yr) were randomized to femoral lipectomy (LIPO) or control (CON) and followed for 1 yr. Regional adiposity was measured by DEXA and CT. A liquid meal labeled with [(14)C]oleic acid was used to trace the appearance of dietary FA in plasma (6-h postprandial TG), breath (24-h oxidation), and SAT (24-h [(14)C]TG storage). Fasting LPL activity was measured in abdominal and femoral SAT. DEXA leg fat mass was reduced after LIPO vs. CON (Δ-1.4 ± 0.7 vs. 0.1 ± 0.5 kg, P < 0.001) and remained reduced at 1 yr (-1.1 ± 1.4 vs. -0.2 ± 0.5 kg, P < 0.05), as did CT thigh subcutaneous fat area (-39.6 ± 36.6 vs. 4.7 ± 14.6 cm(2), P < 0.05); DEXA trunk fat mass and CT visceral fat area were unchanged. Postprandial TG increased (5.9 ± 7.7 vs. -0.6 ± 5.3 × 10(3) mg/dl, P < 0.05) and femoral SAT LPL activity decreased (-21.9 ± 22.3 vs. 10.5 ± 26.5 nmol·min(-1)·g(-1), P < 0.05) 1 yr following LIPO vs. CON. There were no group differences in (14)C-labeled TG appearing in abdominal and femoral SAT or elsewhere. In conclusion, femoral fat remained reduced 1 yr following lipectomy and was accompanied by increased postprandial TG and reduced femoral SAT LPL activity. There were no changes in storage of meal-derived FA or visceral fat. Our data support a protective role for femoral adiposity on circulating TG independent of dietary FA storage and visceral adiposity. (Copyright © 2015 the American Physiological Society.)
Databáze:	MEDLINE
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