Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review.
| Autor: | Dantas AN; Universidade Potiguar (UnP), Natal, RN, Brazil., Morais EF; Universidade Potiguar (UnP), Natal, RN, Brazil., Macedo RA; Universidade Potiguar (UnP), Natal, RN, Brazil., Tinôco JM; Universidade Potiguar (UnP), Natal, RN, Brazil. Electronic address: joao-tinoco@hotmail.com., Morais Mde L; Universidade Potiguar (UnP), Natal, RN, Brazil; Universidade do Estado do Rio Grande do Norte (UERN), Natal, RN, Brazil; Liga Norte-Riogradense contra o Câncer, Natal, RN, Brazil; Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Brazilian journal of otorhinolaryngology [Braz J Otorhinolaryngol] 2015 May-Jun; Vol. 81 (3), pp. 329-35. Date of Electronic Publication: 2015 Mar 30. |
| DOI: | 10.1016/j.bjorl.2014.07.016 |
| Abstrakt: | Introduction: Adenoid cystic carcinoma is the most frequent malignant tumor of the submandibular gland and the minor salivary glands. It is a malignant neoplasm that, despite its slow growth, shows an unfavorable prognosis. Objectives: The aim of this study was to perform a systematic review of the literature on Adenoid cystic carcinoma in the head and neck region and its clinicopathological characteristics, with emphasis on the perineural invasion capacity of the tumor. Methods: A systematic search of articles published between January 2000 and January 2014 was performed in the PubMed/MEDLINE, SciELO, Science Direct, and Scopus databases. Results: Nine articles were selected for this systematic review. These demonstrated that the female gender was more often affected and that malignant tumors showed a high rate of distant metastasis, recurrence, and a low survival rate. The presence of perineural invasion ranged from 29.4% to 62.5% and was associated with local tumor recurrence. Conclusion: Adenoid cystic carcinoma is commonly characterized by the presence of pain, high rate of recurrence, metastasis, and a low survival rate. Reporting studies with patient follow-up is of utmost importance for a better clinical-pathological understanding and to improve the prognosis of this pathology. (Copyright © 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.) |
| Databáze: | MEDLINE |
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