Rhabdomyolysis in the setting of induced hypothyroidism and statin therapy: a case report.

Autor: Jbara Y; Boonshoft School of Medicine, Wright State University, Dayton, Ohio, USA., Bricker D; Boonshoft School of Medicine, Wright State University, Dayton, Ohio, USA.
Jazyk: angličtina
Zdroj: European thyroid journal [Eur Thyroid J] 2015 Mar; Vol. 4 (1), pp. 62-4. Date of Electronic Publication: 2015 Feb 18.
DOI: 10.1159/000371548
Abstrakt: Mild elevation of creatine kinase (CK) is common in untreated hypothyroidism, but severe myositis and overt rhabdomyolysis are rare. Similarly, muscle pain and CK elevation are potential side effects of statin therapy, yet rhabdomyolysis is likewise rare in the absence of medication interactions adversely affecting statin metabolism. The coexistence of statin therapy and hypothyroid states may synergistically increase the risk of myopathy. We describe a case of rhabdomyolysis attributable to induced hypothyroidism in a patient on chronic statin medication who was anticipating adjuvant radioiodine ((131)I) therapy for a thyroid carcinoma.
Databáze: MEDLINE