Impact of Metabolic Syndrome on Subclinical Atherosclerosis in Asymptomatic Individuals.
| Autor: | Park GM; Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea., An H, Lee SW, Cho YR, Gil EH, Her SH, Park HW, Ahn JM, Park DW, Kang SJ, Kim YH, Lee CW, Yang DH, Kang JW, Lim TH, Kim HK, Choe J, Park SW, Park SJ |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2015; Vol. 79 (8), pp. 1799-806. Date of Electronic Publication: 2015 May 08. |
| DOI: | 10.1253/circj.CJ-14-1197 |
| Abstrakt: | Background: Little is known about subclinical atherosclerosis on coronary computed tomographic angiography (CCTA) in asymptomatic individuals with metabolic syndrome (MetS). Methods and Results: We analyzed 5,213 asymptomatic individuals who underwent CCTA. A cardiac event was defined as a composite of all-cause death, myocardial infarction, unstable angina, or coronary revascularization. Of the study participants, 2,042 (39.2%) had MetS. MetS was an independent predictor of significant coronary artery disease (CAD) in at least 1 coronary artery (odds ratio [OR]=1.992, 95% confidence interval [CI]=1.623-2.445, P<0.001) and significant CAD in the left main (LM) or proximal left anterior descending (LAD) artery (OR=2.151, 95% CI=1.523-3.037, P<0.001). During the follow-up period (median 28.1 [interquartile range, 19.2-36.5] months), 111 individuals had 114 cardiac events. Individuals with MetS were significantly associated with more cardiac events than those without (RR [rate ratio]=1.67, 95% CI=1.15-2.43, P=0.007). In the MetS group, individuals with significant CAD had the majority of cardiac events (RR=64.33, 95% CI=29.17-141.88, P<0.001). Furthermore, in the MetS with significant CAD group, those with significant CAD in the LM or proximal LAD had more cardiac events (RR=2.63, 95% CI=1.51-4.59, P=0.001). Conclusions: MetS was associated with subclinical atherosclerosis on CCTA with subsequent high risk for cardiac events. These findings suggest the importance of reducing unfavorable metabolic conditions in asymptomatic individuals. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|