Occult infection with HBV intergenotypic A2/G recombinant following acute hepatitis B caused by an HBV/A2 isolate.

Autor: de Barros JJ; Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil., Peres LR; Laboratório de Referência Nacional para Hepatites Virais, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil., de Sousa PS; Laboratório de Referência Nacional para Hepatites Virais, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil., do Amaral Mello FC; Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil., de Araujo NM; Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil., de Andrade Gomes S; Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil., Niel C; Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil. Electronic address: niel@ioc.fiocruz.br., Lewis-Ximenez LL; Laboratório de Referência Nacional para Hepatites Virais, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil.
Jazyk: angličtina
Zdroj: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2015 Jun; Vol. 67, pp. 31-5. Date of Electronic Publication: 2015 Mar 24.
DOI: 10.1016/j.jcv.2015.03.019
Abstrakt: Viral and host factors leading to occult hepatitis B virus (HBV) infection (OBI) are not fully understood. Whether HBV genotype may influence the occurrence and course of OBIs is unknown. Here, we describe the case of a patient infected with HBV genotype A2 who developed symptomatic acute hepatitis and did not seroconvert after loss of HBsAg and HBeAg. The acute phase of hepatitis B was followed by a period of more than 2 years during which the DNA of an intergenotypic HBV/A2/G recombinant was intermittently detected in serum.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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