A Comparison of Data Driven-based Measures of Adherence to Oral Hypoglycemic Agents in Medicaid Patients.

Autor: Zhu VJ; Regenstrief Institute, IN., Tu W; Regenstrief Institute, IN., Rosenman MB; Regenstrief Institute, IN., Overhage JM; Siemens Healthcare, Malvern, PA.
Jazyk: angličtina
Zdroj: AMIA ... Annual Symposium proceedings. AMIA Symposium [AMIA Annu Symp Proc] 2014 Nov 14; Vol. 2014, pp. 1294-301. Date of Electronic Publication: 2014 Nov 14 (Print Publication: 2014).
Abstrakt: We evaluated and compared different methods for measuring adherence to Oral Antihyperglycemic Agents (OHA), based on the correlation between these measures and glycated hemoglobin A1C (HbA1c) levels in Medicaid patients with Type 2 diabetes. An observational sample of 831 Medicaid patients with Type 2 diabetes who had HbA1c test results recorded between January 1, 2001 and December 31, 2005 was identified in the Indiana Network of Patient Care (INPC). OHA adherence was measured by medication possession ratio (MPR), proportion of days covered (PDC), and the number of gaps (GAP) for 3, 6, and 12-month intervals prior to the HbA1c test date. All three OHA adherence measurements showed consistent and significant correlation with HbA1c level. The 6-month PDC showed the strongest association with HbA1c levels in both unadjusted (-1.07, P<0.0001) and adjusted (-1.12, P<0.0001) models.
Databáze: MEDLINE