Synthesis and characterization of biodegradable polyurethane films based on HDI with hydrolyzable crosslinked bonds and a homogeneous structure for biomedical applications.

Autor: Barrioni BR; Department of Metallurgical Engineering and Materials, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, School of Engineering, Belo Horizonte, MG 31270-901, Brazil. Electronic address: brenobarrionibh@hotmail.com., de Carvalho SM; Department of Metallurgical Engineering and Materials, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, School of Engineering, Belo Horizonte, MG 31270-901, Brazil. Electronic address: sandhra_carvalho@yahoo.com.br., Oréfice RL; Department of Metallurgical Engineering and Materials, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, School of Engineering, Belo Horizonte, MG 31270-901, Brazil. Electronic address: rorefice@demet.ufmg.br., de Oliveira AA; Department of Metallurgical Engineering and Materials, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, School of Engineering, Belo Horizonte, MG 31270-901, Brazil. Electronic address: agdalinero@yahoo.com., Pereira Mde M; Department of Metallurgical Engineering and Materials, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, School of Engineering, Belo Horizonte, MG 31270-901, Brazil. Electronic address: mpereira@demet.ufmg.br.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2015; Vol. 52, pp. 22-30. Date of Electronic Publication: 2015 Mar 24.
DOI: 10.1016/j.msec.2015.03.027
Abstrakt: Synthetic biodegradable polymers are considered strategic in the biomaterials field and are used in various applications. Among the polymers used as biomaterials, polyurethanes (PUs) feature prominently due to their versatility and the ability to obtain products with a wide range of physical and mechanical properties. In this work, new biodegradable polyurethane films were developed based on hexamethylene diisocyanate (HDI) and glycerol as the hard segment (HS), and poly(caprolactone) triol (PCL triol) and low-molecular-weight poly(ethylene glycol) PEG as the soft segment (SS) without the use of a catalyst. The films obtained were characterized by structural, mechanical and biological testing. A highly connected network with a homogeneous PU structure was obtained due to crosslinked bonds. The films showed amorphous structures, high water uptake, hydrogel behavior, and susceptibility to hydrolytic degradation. Mechanical tests indicated that the films reached a high deformation at break of up to 425.4%, an elastic modulus of 1.6 MPa and a tensile strength of 3.6 MPa. The materials presented a moderate toxic effect on MTT assay and can be considered potential materials for biomedical applications.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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