64Cu-DOTATATE PET for Neuroendocrine Tumors: A Prospective Head-to-Head Comparison with 111In-DTPA-Octreotide in 112 Patients.

Autor:	Pfeifer A; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark Department of Nuclear Medicine, Helios-Klinikum Berlin-Buch, Berlin, Germany ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark., Knigge U; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark Departments of Surgical Gastroenterology C and Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark., Binderup T; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark., Mortensen J; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark., Oturai P; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark., Loft A; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark., Berthelsen AK; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark., Langer SW; ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark Department of Oncology, Rigshospitalet, Copenhagen, Denmark; and., Rasmussen P; Hevesy Laboratory, DTU-Risø, Roskilde, Denmark., Elema D; Hevesy Laboratory, DTU-Risø, Roskilde, Denmark., von Benzon E; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark., Højgaard L; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark., Kjaer A; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark ENETS Center of Excellence for Neuroendocrine Tumors, Copenhagen, Denmark akjaer@sund.ku.dk.
Jazyk:	angličtina
Zdroj:	Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2015 Jun; Vol. 56 (6), pp. 847-54. Date of Electronic Publication: 2015 May 07.
DOI:	10.2967/jnumed.115.156539
Abstrakt:	Unlabelled: Neuroendocrine tumors (NETs) can be visualized using radiolabeled somatostatin analogs. We have previously shown the clinical potential of (64)Cu-DOTATATE in a small first-in-human feasibility study. The aim of the present study was, in a larger prospective design, to compare on a head-to-head basis the performance of (64)Cu-DOTATATE and (111)In-diethylenetriaminepentaacetic acid (DTPA)-octreotide ((111)In-DTPA-OC) as a basis for implementing (64)Cu-DOTATATE as a routine. Methods: We prospectively enrolled 112 patients with pathologically confirmed NETs of gastroenteropancreatic or pulmonary origin. All patients underwent both PET/CT with (64)Cu-DOTATATE and SPECT/CT with (111)In-DTPA-OC within 60 d. PET scans were acquired 1 h after injection of 202 MBq (range, 183-232 MBq) of (64)Cu-DOTATATE after a diagnostic contrast-enhanced CT scan. Patients were followed for 42-60 mo for evaluation of discrepant imaging findings. The McNemar test was used to compare the diagnostic performance. Results: Eighty-seven patients were congruently PET- and SPECT-positive. No SPECT-positive cases were PET-negative, whereas 10 false-negative SPECT cases were identified using PET. The diagnostic sensitivity and accuracy of (64)Cu-DOTATATE (97% for both) were significantly better than those of (111)In-DTPA-OC (87% and 88%, respectively, P = 0.017). In 84 patients (75%), (64)Cu-DOTATATE identified more lesions than (111)In-DTPA-OC and always at least as many. In total, twice as many lesions were detected with (64)Cu-DOTATATE than with (111)In-DTPA-OC. Moreover, in 40 of 112 cases (36%) lesions were detected by (64)Cu-DOTATATE in organs not identified as disease-involved by (111)In-DTPA-OC. Conclusion: With these results, we demonstrate that (64)Cu-DOTATATE is far superior to (111)In-DTPA-OC in diagnostic performance in NET patients. Therefore, we do not hesitate to recommend implementation of (64)Cu-DOTATATE as a replacement for (111)In-DTPA-OC. (© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.)
Databáze:	MEDLINE
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