Translational research will fail without surgical leadership: SCOTRRCC a successful surgeon-led Nationwide translational research infrastructure in renal cancer.

Autor: Stewart GD; Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK. Electronic address: grant.stewart@ed.ac.uk., Riddick AC; Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK., Rae F; NHS Lothian, UK., Marshall C; NHS Lothian, UK., MacLeod L; NHS Lothian, UK., O'Mahony FC; Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK., Laird A; Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK., Alan McNeill S; Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK., O'Connor KM; Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK., O'Donnell M; Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK., Fineron P; NHS Lothian, UK., McLaren DB; NHS Lothian, UK., Aitchison M; NHS Greater Glasgow and Clyde, UK., Oades G; NHS Greater Glasgow and Clyde, UK., Hair J; NHS Greater Glasgow and Clyde, UK., Seywright M; NHS Greater Glasgow and Clyde, UK., Little B; NHS Ayrshire and Arran, UK., Nairn R; NHS Ayrshire and Arran, UK., Lamb G; NHS Forth Valley, UK., Macleod T; NHS Forth Valley, UK., Dunn I; NHS Lanarkshire, UK., Ramsey A; NHS Lanarkshire, UK., Campbell R; NHS Lanarkshire, UK., Leung S; NHS Fife, UK., McLornan L; NHS Fife, UK., Rahilly M; NHS Fife, UK., Wilson I; NHS Highland, UK., Pollock AM; NHS Highland, UK., Harrison DJ; Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK; School of Medicine, St. Andrews University, St. Andrews, UK.
Jazyk: angličtina
Zdroj: The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland [Surgeon] 2015 Aug; Vol. 13 (4), pp. 181-6. Date of Electronic Publication: 2015 Apr 30.
DOI: 10.1016/j.surge.2015.03.001
Abstrakt: Background: High quality human biosamples with associated high quality clinical data are essential for successful translational research. Despite this, the traditional approach is for the surgeon to act as a technician in the tissue collection act. Biomarker research presents multiple challenges and the field is littered with failures. Tissue quality, poor clinical information, small sample numbers and lack of validation cohorts are just a few reasons for failure. It is clear that the surgeon involved in tissue acquisition must be fully engaged in the process of biosampling for a specific condition, as this will negate many of the issues for translational research failure due to an inadequate bioresource.
Approach: In this Matter for Debate paper, the Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC) is discussed as an example of a urological surgery lead bioresource which has resulted in a National collection of renal cancer tissue and blood (from over 900 patients to date), negating all of the traditional issues with biobanks because of close enagagement and acknowledgement of urologists and uropathologists from seven centres around Scotland. SCOTRRCC has leveraged renal cancer research in Scotland resulting in several high impact publications and providing a springboard for future research in this disease in Scotland and beyond.
Conclusions: The SCOTRRCC model presented here can be transferred to other surgical disciplines for success in translational research.
(Copyright © 2015 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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