Soluble Megalin is Reduced in Cerebrospinal Fluid Samples of Alzheimer's Disease Patients.

Autor:	Spuch C; Department of Neurology, Instituto de Investigación Biomédica de Ourense, Pontevedra y Vigo (IBI)/Xerencia de Xestión Integrada de Vigo-SERGAS , Vigo , Spain., Antequera D; Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) , Madrid , Spain ; Neuroscience Group, Research Institute Hospital , Madrid , Spain., Pascual C; Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) , Madrid , Spain ; Neuroscience Group, Research Institute Hospital , Madrid , Spain., Abilleira S; Department of Neurology, Instituto de Investigación Biomédica de Ourense, Pontevedra y Vigo (IBI)/Xerencia de Xestión Integrada de Vigo-SERGAS , Vigo , Spain., Blanco M; Department of Neurology, Instituto de Investigación Biomédica de Ourense, Pontevedra y Vigo (IBI)/Xerencia de Xestión Integrada de Vigo-SERGAS , Vigo , Spain., Moreno-Carretero MJ; Department of Neurology, Instituto de Investigación Biomédica de Ourense, Pontevedra y Vigo (IBI)/Xerencia de Xestión Integrada de Vigo-SERGAS , Vigo , Spain., Romero-López J; Department of Neurology, Instituto de Investigación Biomédica de Ourense, Pontevedra y Vigo (IBI)/Xerencia de Xestión Integrada de Vigo-SERGAS , Vigo , Spain., Ishida T; Department of Histology and Cell Biology, School of Medicine, Kagawa University , Miki , Japan., Molina JA; Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) , Madrid , Spain ; Service of Neurology, Research Institute Hospital , Madrid , Spain., Villarejo A; Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) , Madrid , Spain ; Service of Neurology, Research Institute Hospital , Madrid , Spain., Bermejo-Pareja F; Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) , Madrid , Spain ; Service of Neurology, Research Institute Hospital , Madrid , Spain., Carro E; Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) , Madrid , Spain ; Neuroscience Group, Research Institute Hospital , Madrid , Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular neuroscience [Front Cell Neurosci] 2015 Apr 15; Vol. 9, pp. 134. Date of Electronic Publication: 2015 Apr 15 (Print Publication: 2015).
DOI:	10.3389/fncel.2015.00134
Abstrakt:	Megalin or low-density lipoprotein receptor-related protein-2 is a member of the low-density lipoprotein receptor family, which has been linked to Alzheimer's disease (AD) by clearing brain amyloid β-peptide (Aβ) across the blood-cerebrospinal fluid barrier at the choroid plexus. Here, we found a soluble form of megalin secreted from choroid plexus epithelial cells. Soluble megalin levels were also localized in the human cerebrospinal fluid (CSF), being reduced in AD patients. We have also shown that soluble megalin binding to Aβ is decreased in the CSF of AD patients, suggesting that decreased sequestration of Aβ in the CSF could be associated with defective clearance of Aβ and an increase of brain Aβ levels. Thus, therapies, which increase megalin expression, at the choroid plexus and/or enhance circulating soluble megalin hold potential to control brain Aβ-related pathologies in AD.
Databáze:	MEDLINE
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