Multicenter Semiquantitative Evaluation of (123)I-FP-CIT Brain SPECT.

Autor: Skanjeti A; Nuclear Medicine Unit, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy.; Medical Science Department, University A. Avogadro, Novara, Italy., Castellano G; Nuclear Medicine Unit, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy., Elia BO; Nuclear Medicine Unit, Umberto I Hospital, Turin, Italy., Zotta M; Nuclear Medicine Unit, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy., Dazzara F; Nuclear Medicine Unit, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy., Manfredi M; Nuclear Medicine Unit, San Giovanni Battista Hospital, University of Turin, Turin, Italy., Galati A; Nuclear Medicine Unit, San Giovanni Battista Hospital, University of Turin, Turin, Italy., Grimaldi S; Nuclear Medicine Unit, San Giovanni Battista Hospital, University of Turin, Turin, Italy., Balma M; Nuclear Medicine Unit, San Giovanni Battista Hospital, University of Turin, Turin, Italy., Pellerito RE; Nuclear Medicine Unit, Umberto I Hospital, Turin, Italy., Podio V; Nuclear Medicine Unit, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy.
Jazyk: angličtina
Zdroj: Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2015 Nov-Dec; Vol. 25 (6), pp. 1023-9. Date of Electronic Publication: 2015 Apr 29.
DOI: 10.1111/jon.12242
Abstrakt: Aims: The aims of this study were: (1) to cross-compare data from semiquantitative, software-assisted, and phantom-corrected evaluations of (123)I-ioflupane [(123)I]N-ω-fluoropropyl-2β-carbomethoxy-3β-{4-iodophenyl}nortropane FP-CIT brain single-photon emission computed tomography (SPECT) acquired in three centers; (2) to assess the accuracy of semiquantitative evaluation; and (3) to identify the threshold with the best accuracy, sensitivity, and specificity in patients with suspected Parkinsonian Syndrome.
Material and Methods: Two-hundred-twenty patients, acquired in three centers, were included. All of them underwent (123)I-FP-CIT brain SPECT. All examinations were analyzed with the freely available software, BasGan, and semiquantitative data were used to predict disease. Analysis was based on the values from the most deteriorated putamen and caudate, normalized for age, and corrected by anthropomorphic phantom data. Receiver operating characteristic (ROC) analysis was performed and areas under the curve (AUC) were estimated.
Results: Analysis showed high AUCs (.880, .866, .920, and .882 for each center and multicenter setting). Best thresholds were 1.53 and 1.56 for putamen and caudate, respectively. Thresholds of putamen data showed sensitivity and specificity of 86% and 89%, respectively, in the multicenter setting. Neither sensibility nor specificity showed significant differences among centers.
Conclusion: A unique, accurate threshold for all centers, with high sensitivity and specificity was identified. Semiquantitative assessment of (123)I-FP-CIT brain SPECT among different centers resulted reliable, accurate, and potentially useful in clinical trials.
(Copyright © 2015 by the American Society of Neuroimaging.)
Databáze: MEDLINE
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