Parainfluenza virus as a cause of acute respiratory infection in hospitalized children.

Autor:	Pecchini R; Medical Shool, Santa Casa de São Paulo, São Paulo, SP, Brazil., Berezin EN; Medical Shool, Santa Casa de São Paulo, São Paulo, SP, Brazil. Electronic address: eberezin2003@yahoo.com., Souza MC; Center for Immunology, Instituto Adolfo Lutz, São Paulo, SP, Brazil., Vaz-de-Lima Lde A; Center for Immunology, Instituto Adolfo Lutz, São Paulo, SP, Brazil., Sato N; Center for Immunology, Instituto Adolfo Lutz, São Paulo, SP, Brazil., Salgado M; Center for Immunology, Instituto Adolfo Lutz, São Paulo, SP, Brazil., Ueda M; Center for Immunology, Instituto Adolfo Lutz, São Paulo, SP, Brazil., Passos SD; Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil., Rangel R; Irmandade da Santa Casa de Misericórdia de São Paulo, SP, Brazil., Catebelota A; Irmandade da Santa Casa de Misericórdia de São Paulo, SP, Brazil.
Jazyk:	angličtina
Zdroj:	The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2015 Jul-Aug; Vol. 19 (4), pp. 358-62. Date of Electronic Publication: 2015 Apr 25.
DOI:	10.1016/j.bjid.2015.03.002
Abstrakt:	Background: Human parainfluenza viruses account for a significant proportion of lower respiratory tract infections in children. Objective: To assess the prevalence of Human parainfluenza viruses as a cause of acute respiratory infection and to compare clinical data for this infection against those of the human respiratory syncytial virus. Methods: A prospective study in children younger than five years with acute respiratory infection was conducted. Detection of respiratory viruses in nasopharyngeal aspirate samples was performed using the indirect immunofluorescence reaction. Length of hospital stay, age, clinical history and physical exam, clinical diagnoses, and evolution (admission to Intensive Care Unit or general ward, discharge or death) were assessed. Past personal (premature birth and cardiopathy) as well as family (smoking and atopy) medical factors were also assessed. Results: A total of 585 patients were included with a median age of 7.9 months and median hospital stay of six days. No difference between the HRSV+ and HPIV+ groups was found in terms of age, gender or length of hospital stay. The HRSV+ group had more fever and cough. Need for admission to the Intensive Care Unit was similar for both groups but more deaths were recorded in the HPIV+ group. The occurrence of parainfluenza peaked during the autumn in the first two years of the study. Conclusion: Parainfluenza was responsible for significant morbidity, proving to be the second-most prevalent viral agent in this population after respiratory syncytial virus. No difference in clinical presentation was found between the two groups, but mortality was higher in the HPIV+ group. (Copyright © 2015. Published by Elsevier Editora Ltda.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu