| Autor: |
Nikitin AG, Potapov VA, Brovkin AN, Lavrikova EIu, Hodyrev DS, Shamkhalova MSh, Smetanina SA, Suplotova LN, Shestakova MV, Nosikov VV, Aver'ianov AV |
| Jazyk: |
ruština |
| Zdroj: |
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2015 Jan-Feb; Vol. 49 (1), pp. 119-28. |
| Abstrakt: |
To study the association with diabetes mellitus type 2 we performed anal- ysis of the distribution of frequencies of alleles and genotypes of polymorphic markers of FTO, KCNJ11, SIC30A8 and CDKN2B genes. The study included groups of T2DM patients and unrelated controls of Russian origin. Analysis of the distribution of frequencies of alleles and genotypes of the polymorphic markers of KCNJ11, SLC30A8 and CDKN2B genes showed the presence of association with T2DM in Russian population, while for the FTO gene was not found statistically significant associations with type 2 diabetes. We can conclude that in Russian population main role in the development of type 2 diabetes play genes, affecting the level of syn- thesis and secretion of the insulin in beta-cells of the pancreas. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
