Human epidermal growth factor receptor 2 expression in mixed gastric carcinoma.

Autor:	Wang YK; Yang-Kun Wang, Tian Yun, Xue-Xia Lv, Department of Pathology, 150 Luoyang Center Hospital, Luoyang 471031, Henan Province, China., Chen Z; Yang-Kun Wang, Tian Yun, Xue-Xia Lv, Department of Pathology, 150 Luoyang Center Hospital, Luoyang 471031, Henan Province, China., Yun T; Yang-Kun Wang, Tian Yun, Xue-Xia Lv, Department of Pathology, 150 Luoyang Center Hospital, Luoyang 471031, Henan Province, China., Li CY; Yang-Kun Wang, Tian Yun, Xue-Xia Lv, Department of Pathology, 150 Luoyang Center Hospital, Luoyang 471031, Henan Province, China., Jiang B; Yang-Kun Wang, Tian Yun, Xue-Xia Lv, Department of Pathology, 150 Luoyang Center Hospital, Luoyang 471031, Henan Province, China., Lv XX; Yang-Kun Wang, Tian Yun, Xue-Xia Lv, Department of Pathology, 150 Luoyang Center Hospital, Luoyang 471031, Henan Province, China., Chu GH; Yang-Kun Wang, Tian Yun, Xue-Xia Lv, Department of Pathology, 150 Luoyang Center Hospital, Luoyang 471031, Henan Province, China., Wang SN; Yang-Kun Wang, Tian Yun, Xue-Xia Lv, Department of Pathology, 150 Luoyang Center Hospital, Luoyang 471031, Henan Province, China., Yan H; Yang-Kun Wang, Tian Yun, Xue-Xia Lv, Department of Pathology, 150 Luoyang Center Hospital, Luoyang 471031, Henan Province, China., Shi LF; Yang-Kun Wang, Tian Yun, Xue-Xia Lv, Department of Pathology, 150 Luoyang Center Hospital, Luoyang 471031, Henan Province, China.
Jazyk:	angličtina
Zdroj:	World journal of gastroenterology [World J Gastroenterol] 2015 Apr 21; Vol. 21 (15), pp. 4680-7.
DOI:	10.3748/wjg.v21.i15.4680
Abstrakt:	Aim: To investigate human epidermal growth factor receptor 2 (HER2) amplification and protein expression in mixed gastric carcinoma. Methods: Fluorescence in situ hybridization and immunohistochemistry were used to detect HER2 amplification and protein expression in 277 cases of mixed gastric carcinoma. Protein staining intensity was rate as 1+, 2+, or 3+. Results: Of the 277 cases, 114 (41.2%) expressed HER2 protein. HER2 3+ staining was observed in 28/277 (10.1%) cases, 2+ in 37/277 (13.4%) cases, and 1+ in 49/277 (17.7%) cases. A HER2 amplification rate of 17% was detected, of which 25/28 (89.3%) were observed in the HER2 3+ staining group, 17/37 (45.9%) in 2+, and 5/49 (10.2%) in 1+. Of the 47 patients with HER2 amplification who received chemotherapy plus trastuzumab, 22 demonstrated median progression-free and overall survivals of 9.1 mo and 16.7 mo, respectively, which were significantly better than those achieved with chemotherapy alone (5.6 mo and 12.1 mo, respectively) in 19 previously treated patients (Ps < 0.05). Conclusion: HER2 detection in mixed gastric carcinoma displays high heterogeneity. Relatively quantitative parameters are needed for assessing the level of HER2 amplification and protein expression.
Databáze:	MEDLINE
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