| Autor: |
Kazakova OB, Giniiatullina GV, Medvedeva NI, Lopatina TV, Baĭkova IP, Tolstikov GA, Apryshko GN |
| Jazyk: |
ruština |
| Zdroj: |
Bioorganicheskaia khimiia [Bioorg Khim] 2014 Mar-Apr; Vol. 40 (2), pp. 217-25. |
| DOI: |
10.1134/s106816201402006x |
| Abstrakt: |
Synthesis of 3-deoxy-3a-homo-3a-aza-derivatives of betulin and erythrodiol from betulonic and oleanonic acids was carried out. The most antineoplastic activity with a wide range of action at in vitro testing showed 3-deoxy-3a-homo-3a-aza-28-hydroxy-12(13)-oleanene, which by results of profound studying could be recommended for in vivo investigation. Its modification in the C28 position by introduction of amethoxycinnamoyl fragment led to a loss of antineoplastic activity. 3-Deoxy-3a-homo-3a-aza-derivatives of betulin (3-(aminopropyl)-, 28-(2-carboxyethyl)carboxy-, and 28-cinnamoyloxy-) showed moderate antineoplastic activity in the case of Colon Cancer, Breast Cancer and Leukemia cell lines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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