α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.

Autor: VanderHorst VG; Departments of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Samardzic T; Departments of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Saper CB; Departments of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Anderson MP; Departments of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.; Departments of Neurology Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Nag S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.; Department of Pathology, Rush University Medical Center, Chicago, IL., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.; Department of Pathology, Rush University Medical Center, Chicago, IL.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL., Buchman AS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
Jazyk: angličtina
Zdroj: Annals of neurology [Ann Neurol] 2015 Jul; Vol. 78 (1), pp. 142-9. Date of Electronic Publication: 2015 May 25.
DOI: 10.1002/ana.24430
Abstrakt: Urinary urgency and frequency are common in α-synucleinopathies such as Parkinson disease, Lewy body dementia, and multiple system atrophy. These symptoms cannot be managed with dopamine therapy, and their underlying pathophysiology is unclear. We show that in individuals with Parkinson disease, Lewy body dementia, or multiple system atrophy, α-synuclein pathology accumulates in the lateral collateral pathway, a region of the sacral spinal dorsal horn important for the relay of pelvic visceral afferents. Deposition of α-synuclein in this region may contribute to impaired micturition and/or constipation in Parkinson disease and other α-synucleinopathies.
(© 2015 American Neurological Association.)
Databáze: MEDLINE
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