Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center.
Autor: | Hoch RV; Department of Psychiatry, University of California, 1550 4th Street, UCSF MC 2611, San Francisco, CA, 94158, USA. rhoch@plos.org.; Current address: PLOS, 1160 Battery Street, San Francisco, CA, 94111, USA. rhoch@plos.org., Clarke JA; Department of Psychiatry, University of California, 1550 4th Street, UCSF MC 2611, San Francisco, CA, 94158, USA. jefclarke@gmail.com., Rubenstein JL; Department of Psychiatry, University of California, 1550 4th Street, UCSF MC 2611, San Francisco, CA, 94158, USA. john.rubenstein@ucsf.edu. |
---|---|
Jazyk: | angličtina |
Zdroj: | Neural development [Neural Dev] 2015 Mar 31; Vol. 10, pp. 8. Date of Electronic Publication: 2015 Mar 31. |
DOI: | 10.1186/s13064-015-0037-7 |
Abstrakt: | Background: The rostral patterning center (RPC) secretes multiple fibroblast growth factors (Fgfs) essential for telencephalon growth and patterning. Fgf expression patterns suggest that they mark functionally distinct RPC subdomains. We generated Fgf8(CreER) and Fgf17(CreER) mice and used them to analyze the lineages of Fgf8- versus Fgf17-expressing RPC cells. Results: Both lineages contributed to medial structures of the rostroventral telencephalon structures including the septum and medial prefrontral cortex. In addition, RPC-derived progenitors were observed in other regions of the early telencephalic neuroepithelium and generated neurons in the olfactory bulb, neocortex, and basal ganglia. Surprisingly, Fgf8(+) RPC progenitors generated the majority of basal ganglia cholinergic neurons. Compared to the Fgf8 lineage, the Fgf17 lineage was more restricted in its early dispersion and its contributions to the telencephalon. Mutant studies suggested that Fgf8 and Fgf17 restrict spread of RPC progenitor subpopulations. Conclusions: We identified the RPC as an important source of progenitors that contribute broadly to the telencephalon and found that two molecularly distinct progenitor subtypes in the RPC make different contributions to the developing forebrain. |
Databáze: | MEDLINE |
Externí odkaz: |