High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil.

Autor: Bandeira LM; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Uehara SN; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Asato MA; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Aguena GS; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Maedo CM; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Benites NH; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Puga MA; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Rezende GR; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Finotti CM; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Cesar GA; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Tanaka TS; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Castro VO; Central Public Health Laboratory, LACEN/MS, Camp Grande, Mato Grosso do Sul, Brazil., Otsuki K; Laboratory of Molecular Genetics of Microorganisms and Oswaldo Cruz Institute, Rio de Janeiro, Brazil., Vicente AC; Laboratory of Molecular Genetics of Microorganisms and Oswaldo Cruz Institute, Rio de Janeiro, Brazil., Fernandes CE; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Motta-Castro AR; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil; Oswaldo Cruz Foundation, Campo Grande, Mato Grosso do Sul, Brazil.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2015 Apr 17; Vol. 9 (4), pp. e0003691. Date of Electronic Publication: 2015 Apr 17 (Print Publication: 2015).
DOI: 10.1371/journal.pntd.0003691
Abstrakt: Background: Human T-lymphotropic virus type 1 (HTLV-1) has worldwide distribution and is considered endemic in many world regions, including southwestern Japan and Brazil. Japanese immigrants and their descendants have a high risk of acquiring this infection due to intense population exchange between Brazil and Japan.
Objective: This cross-sectional study aimed to estimate the prevalence of HTLV, analyze the main risk factors associated with this infection, identify the main circulating types and subtypes of HTLV in Japanese immigrants and descendants living in Campo Grande-MS (Middle-West Brazil), as well as analyze the phylogenetic relationship among isolates of HTLV.
Study Design: A total of 219 individuals were interviewed and submitted to blood collection. All collected blood samples were submitted for detection of anti-HTLV-1/2 using the immunoassay ELISA and confirmed by immunoblot method. The proviral DNA of the 14 samples HTLV- 1 positive were genotyped by nucleotide sequencing.
Results: The overall prevalence of HTLV-1 was 6.8% (IC 95%: 3,5-10,2). Descriptive analysis of behavioral risk factors showed statistical association between HTLV-1 and age greater than or equal to 45 years. The proviral DNA of HTLV-1 was detected in all HTLV-1 positive samples. Of these, 14 were sequenced and classified as Cosmopolitan subtype, and 50% (7/14) belonged to subgroup A (transcontinental) and 50% (7/14) to the subgroup B (Japanese).
Conclusion: The high prevalence of HTLV-1 found evidence of the importance of early diagnosis and counseling of individuals infected with HTLV-1 for the control and prevention of the spread of this infection among Japanese immigrants and their descendants in Central Brazil.
Databáze: MEDLINE
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