Influence of Altered Hormonal Status on Platelet 5-HT and MAO-B Activity in Cigarette Smokers.

Autor: Padmavathi P; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515-003 AP India., Reddy VD; Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637 USA., Swarnalatha K; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515-003 AP India., Hymavathi R; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515-003 AP India., Varadacharyulu NCh; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515-003 AP India.
Jazyk: angličtina
Zdroj: Indian journal of clinical biochemistry : IJCB [Indian J Clin Biochem] 2015 Apr; Vol. 30 (2), pp. 204-9. Date of Electronic Publication: 2014 Feb 11.
DOI: 10.1007/s12291-014-0425-5
Abstrakt: The present study was designed to understand the cigarette smoking-induced alterations in hormones and the resulting changes in platelet serotonin (5-hydroxytryptamine, 5-HT) and monoamine oxidase (MAO-B) activity in chronic smokers. Human male volunteers aged 35 ± 8 years, were divided into two groups, namely controls and smokers (12 ± 2 cigarettes per day for 7-10 years). Results showed that cigarette smoking significantly (p < 0.05) elevated plasma triiodothyronine (T3), cortisol and testosterone levels with significant (p < 0.05) reduction in plasma tryptophan and thyroxin (T4). Moreover, smokers showed reduced platelet 5-HT levels and MAO-B activity. In smokers, plasma cortisol was negatively correlated with tryptophan (r = -0.386), platelet MAO-B (r = -0.264), and 5-HT (r = -0.671), and positively correlated with testosterone (r = 0.428). However, testosterone was negatively correlated with platelet MAO-B (r = -0.315), and 5-HT (r = -.419) in smokers. Further, smokers plasma T3 levels were negatively correlated with platelet MAO-B (r = -0.398), and 5-HT (r = -0.541), whereas T4 levels were positively correlated with platelet MAO-B (r = 0.369), and 5-HT (r = 0.454). In conclusion, our study showed that altered testosterone and cortisol levels may aggravate behavior, mood disturbances and symptoms of depression by decreasing platelet 5-HT and MAO-B activity in smokers.
Databáze: MEDLINE
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