Surgical experience of adult primary hepatic sarcomas.

Autor: Lin YH; Department of Surgery of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung, Kaohsiung, 83301, Taiwan. adrianlin107@gmail.com., Lin CC; Department of Surgery of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung, Kaohsiung, 83301, Taiwan. immunologylin@gmail.com., Concejero AM; Department of Surgery of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung, Kaohsiung, 83301, Taiwan. allanc_md@yahoo.com., Yong CC; Department of Surgery of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung, Kaohsiung, 83301, Taiwan. yong3980@hotmail.com., Kuo FY; Department of Pathology of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan. kuofy@cgmh.org.tw., Wang CC; Department of Surgery of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung, Kaohsiung, 83301, Taiwan. ufel4996@gmail.com.
Jazyk: angličtina
Zdroj: World journal of surgical oncology [World J Surg Oncol] 2015 Feb 28; Vol. 13, pp. 87. Date of Electronic Publication: 2015 Feb 28.
DOI: 10.1186/s12957-015-0489-6
Abstrakt: Background: Primary hepatic sarcoma (PHS) is a rare primary liver malignancy. The histological types of PHS are diverse, and the clinical outcomes and management mainly depend on the histopathology. This study aims to evaluate the results of surgical intervention.
Methods: Between January 2003 and June 2009, 13 adult patients with pathologically proven PHS were identified by record review. The patients' demographic profile, tumor characteristics, treatment modalities, and outcomes were reviewed and analyzed. The end of follow-up was December 2014.
Results: Nine (69%) underwent curative liver resection and two underwent liver transplantation; the others received non-operative treatments. The pathologic findings were six (46%) angiosarcomas, four (30.7%) undifferentiated sarcomas, one (7.6%) leiomyosarcoma, one (7.6%) malignant mesenchymoma, and one (7.6%) hepatic epithelioid hemangioendothelioma. The median follow-up was 31.4 (2.8 ~ 142.5) months. The 1-, 2-, and 5-year survival of surgical patients were 72.7%, 63.6%, and 36.4%, respectively. Importantly, the 1-, 2-, and 5-year survival rates of non-angiosarcoma patients were superior to those of angiosarcoma (85.7% vs. 33.3%, 71.4% vs. 16.7%, and 57.1% vs. 0%, respectively, P = 0.023).
Conclusions: Surgical intervention provides the possibility of long-term survival from PHS. Angiosarcoma is associated with a more dismal outcome than non-angiosarcoma.
Databáze: MEDLINE
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