Incidence of retinopathy in chronic hepatitis C patients treated with pegylated interferon alpha 2a and ribavirin combination therapy.
| Autor: | Kashif M, Saleem MK; Dr. Muhammad Khurram Saleem, Assistant Professor of Medicine, CMH Lahore Medical College, Combined Military Hospital Lahore, Pakistan., Farooka IK; Dr. Imran Khan Farooka, Senior Registrar Medicine, Medical Unit II, Jinnah Hospital Lahore, Pakistan., Husnain A; Dr. Amina Husnain, Assistant Professor of Medicine, Medical Unit II, Jinnah Hospital Lahore, Pakistan., Siddiqui AM; Prof. Dr. Arif Mahmood Siddiqui, Head of Department, Medical Unit II, Jinnah Hospital Lahore, Pakistan. |
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| Jazyk: | angličtina |
| Zdroj: | Pakistan journal of medical sciences [Pak J Med Sci] 2015 Jan-Feb; Vol. 31 (1), pp. 174-7. |
| DOI: | 10.12669/pjms.311.6321 |
| Abstrakt: | Objectives: The objective of this study was to determine the incidence of retinopathy in chronic hepatitis C patients treated with Pegylated interferon alpha 2a and Ribavirin. Methods: This descriptive case series study was conducted in Medical Unit II of the Jinnah Hospital Lahore from September 2012 to February 2013. One hundred chronic hepatitis C patients visiting Medical Unit II outpatient department fulfilling inclusion criteria were selected for this study via non probability purposive sampling. Patients were started on pegylated interferon and ribavirin combination therapy. Subjects were subjected to dilated eye fundoscopic examination at the start of therapy and then after three months of the therapy. Results: One hundred patients were included in this study. Out of these 100 patients 5% developed retinopathy whereas fundus examination was normal in rest of the patients. Conclusion: Interferon therapy can lead to retinopathy. Periodic fundoscopic examinations help in early detection and prevent progression to permanent visual loss. |
| Databáze: | MEDLINE |
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