GAS6 intron 8 c.834 + 7G > A gene polymorphism in diabetic nephropathy.

Autor: Erkoc R; a Division of Nephrology, Department of Internal Medicine, Faculty of Medicine , Bezmialem Vakif University , Istanbul , Turkey ., Cikrikcioglu MA, Aintab E, Toprak AE, Kilic U, Gok O, Cetin AI, Zorlu M, Kiskac M, Cakirca M, Erkal SN, Isen HC, Karatoprak C
Jazyk: angličtina
Zdroj: Renal failure [Ren Fail] 2015 Jun; Vol. 37 (5), pp. 866-70. Date of Electronic Publication: 2015 Apr 14.
DOI: 10.3109/0886022X.2015.1034606
Abstrakt: Unlabelled: BACKGROUND - AIM: In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic nephropathy is prevented by warfarin-induced inhibition of GAS6 protein. It was shown that GAS6 intron 8 c.834 + 7G > A polymorphism is protective against type 2 diabetes mellitus, and AA genotype is associated with higher blood levels of GAS6 protein. Our aim is to investigate whether this polymorphism is a risk factor for diabetic nephropathy in type 2 diabetes mellitus.
Method: Eighty-seven patients with diabetic nephropathy were compared with 66 non-diabetic controls in terms of GAS6 intron 8 c.834 + 7G > A polymorphism. Patients with history of stroke, ischemic heart disease were excluded. Each patient was examined by the ophthalmologist to determine diabetic retinopathy.
Results: Frequency of GG, GA and AA genotypes are similar in diabetic nephropathy and control groups according to GAS6 intron 8 c.834 + 7G > A polymorphism (p =  .837). Rate of diabetic retinopathy was 54.02%. In the subgroup analysis, GA genotype was significantly more frequent than GG genotype in patients with diabetic retinopathy when compared to without diabetic retinopathy (p =  .010).
Conclusion: In our study, GAS6 intron 8 c.834 + 7G > A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy.
Databáze: MEDLINE
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