Effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia.

Autor: Comim CM; Laboratory of Neuropathology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil. Electronic address: clarissamc@gmail.com.br., Silva NC; Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil., Patrício JJ; Laboratory of Neuropathology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil., Palmas D; Laboratory of Neuropathology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil., Mendonça BP; Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil., Bittencourt MO; Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil., Cassol OJ Jr; Laboratory of Neuropathology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil., Barichello T; Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil., Zugno AI; Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil., Quevedo J; Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil; Center for Experimental Models in Psychiatry, Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School at Houston, Houston, TX, USA., Dal-Pizzol F; Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2015 Apr 15; Vol. 281, pp. 78-82. Date of Electronic Publication: 2015 Mar 03.
DOI: 10.1016/j.jneuroim.2015.02.012
Abstrakt: This study aimed to evaluate the effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia. Male Wistar rats underwent Cecal Ligation and Perporation (CLP) with "basic support" or were sham-operated. After 30 days, the animals were submitted to a model of schizophrenia by injection of Ketamine. The behavior tests were performed after 30 min of the injection of Ketamine or saline. Ketamine in doses of 15 and 25mg/kg increased locomotor activity, latency to first contact in the social interaction and stereotyped behavior. Some changes caused by sepsis may be associated with a predisposition to develop schizophrenia in the animal model.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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