Neurophysiological monitoring during acute and progressive experimentally induced compression injury of the spinal cord in pigs.

Autor: Montes E; Department of Clinical Neurophysiology, Hospital Ramón y Cajal, Madrid, Spain., Burgos J; Division of Pediatric Orthopedics, Hospital Ramón y Cajal, Madrid, Spain., Barrios C; Institute for Research on Musculoskeletal Disorders, Valencia Catholic University, Quevedo 2, 46001, Valencia, Spain. carlos.barrios@ucv.es., de Blas G; Department of Clinical Neurophysiology, Hospital Ramón y Cajal, Madrid, Spain., Hevia E; Spine Surgery Unit, Hospital La Fraternidad-Muprexpa, Madrid, Spain., Forteza J; Instituto Valenciano de Patología, Valencia Catholic University, Valencia, Spain.
Jazyk: angličtina
Zdroj: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society [Eur Spine J] 2017 Jan; Vol. 26 (1), pp. 49-55. Date of Electronic Publication: 2015 Apr 11.
DOI: 10.1007/s00586-015-3924-z
Abstrakt: Purpose: To evaluate the degree of acute or progressive lateral compression needed to cause neurologic injury to the spinal cord assessed by electrophysiological monitoring.
Methods: In five domestic pigs, the spinal cord was exposed and compressed between T8-T9 roots using a precise compression device. Two sticks placed on both sides of the spinal cord were sequentially brought together (0.5 mm every 2 min), causing progressive spinal cord compression. Acute compression was reproduced by a 2.5-mm displacement of the sticks. Cord-to-cord evoked potentials were obtained with two epidural catheters.
Results: Increasing latency and decreasing amplitude of the evoked potentials were observed after a mean progressive displacement of the sticks of 3.2 ± 0.9 mm, disappearing after a mean displacement of 4.6 ± 1.2 mm. The potential returned after compression removal (16.8 ± 3.2 min). The potentials disappeared immediately after an acute compression of 2.5 ± 0.3 mm, without any sign of recovering after 30 min.
Conclusions: The experimental model replicates the mechanism of a spinal cord injury caused by medially displaced screws into the spinal canal. The spinal cord had more ability for adaptation to progressive and slow compression than to acute mechanisms.
Databáze: MEDLINE
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