Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.

Autor:	Ma J; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Divers J; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Palmer ND; Center for Genomics & Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Julian BA; Department of Medicine, Division of Nephrology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA., Israni AK; Department of Medicine, Division of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota, USA.; Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA., Schladt D; Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA., Pastan SO; Department of Medicine, Renal Division, Emory University School of Medicine, Atlanta, Georgia, USA., Chattrabhuti K; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Gautreaux MD; General Surgery & HLA Immunogenetics Lab, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Hauptfeld V; Alabama Regional Histocompatibility Laboratory at UAB, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA., Bray RA; Department of Pathology & Lab Medicine; Emory School of Medicine, Atlanta, Georgia, USA., Kirk AD; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA., Brown WM; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Gaston RS; Department of Medicine, Division of Nephrology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA., Rogers J; Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Farney AC; Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Orlando G; Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Stratta RJ; Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Guan M; Center for Genomics & Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Palanisamy A; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Reeves-Daniel AM; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Bowden DW; Center for Genomics & Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Langefeld CD; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Hicks PJ; Center for Genomics & Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Ma L; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Genomics & Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Jazyk:	angličtina
Zdroj:	Kidney international [Kidney Int] 2015 Sep; Vol. 88 (3), pp. 584-92. Date of Electronic Publication: 2015 Apr 08.
DOI:	10.1038/ki.2015.105
Abstrakt:	Variants in donor multidrug resistance protein 1 (ABCB1) and caveolin 1 (CAV1) genes are associated with renal allograft failure after transplantation in Europeans. Here we assessed transplantation outcomes of kidneys from 368 African American (AA) and 314 European American (EA) deceased donors based on 38 single-nucleotide polymorphisms (SNPs) spanning ABCB1 and 16 SNPs spanning CAV1, including previously associated index and haplotype-tagging SNPs. Tests for association with time to allograft failure were performed for the 1233 resultant kidney transplantations, adjusting for recipient age, sex, ethnicity, cold ischemia time, panel reactive antibody, human leukocyte antigen match, expanded-criteria donation, and APOL1-nephropathy variants in AA donors. Interaction analyses between APOL1 with ABCB1 and CAV1 were performed. In a meta-analysis of all transplantations, ABCB1 index SNP rs1045642 was associated with time to allograft failure and other ABCB1 SNPs were nominally associated, but not CAV1 SNPs. ABCB1 SNP rs1045642 showed consistent effects with the 558 transplantations from EA donors, but not with the 675 transplantations from AA donors. ABCB1 SNP rs956825 and CAV1 SNP rs6466583 interacted with APOL1 in transplants from AA donors. Thus, the T allele at ABCB1 rs1045642 is associated with shorter renal allograft survival for kidneys from American donors. Interactions between ABCB1 and CAV1 with APOL1 may influence allograft failure for transplanted kidneys from AA donors.
Databáze:	MEDLINE
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