Membrane bound O-acyltransferases and their inhibitors.

Autor:	Masumoto N; Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K., Lanyon-Hogg T; Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K., Rodgers UR; ‡Molecular Medicine Section, National Lung & Heart Institute, Sir Alexander Fleming Building, South Kensington Campus, Imperial College London, SW7 2AZ, U.K., Konitsiotis AD; ‡Molecular Medicine Section, National Lung & Heart Institute, Sir Alexander Fleming Building, South Kensington Campus, Imperial College London, SW7 2AZ, U.K., Magee AI; †Institute of Chemical Biology, Department of Chemistry, Imperial College London, SW7 2AZ, U.K., Tate EW; Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K.
Jazyk:	angličtina
Zdroj:	Biochemical Society transactions [Biochem Soc Trans] 2015 Apr; Vol. 43 (2), pp. 246-52.
DOI:	10.1042/BST20150018
Abstrakt:	Since the identification of the membrane-bound O-acyltransferase (MBOATs) protein family in the early 2000s, three distinct members [porcupine (PORCN), hedgehog (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides. In this review, topology determination, development of assays to measure enzymatic activities and discovery of small molecule inhibitors are compared and discussed for each of these enzymes.
Databáze:	MEDLINE
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