Glatiramer acetate-induced lobular panniculitis and skin necrosis.

Autor: Watkins CE; Quillen College of Medicine, East Tennessee State University, PO Box 70580, Johnson City, TN 37614, USA. watkince@goldmail.etsu.edu., Litchfield J, Youngberg G, Leicht SS, Krishnaswamy G
Jazyk: angličtina
Zdroj: Cutis [Cutis] 2015 Mar; Vol. 95 (3), pp. E26-30.
Abstrakt: Glatiramer acetate (GA) is a drug that commonly is used for the treatment of relapsing-remitting multiple sclerosis (RRMS). Although it typically is known as a safe and effective therapy, a number of adverse effects associated with GA have been reported in the literature. Local injection-site reactions (LISRs) and mild systemic symptoms are among the most commonly described adverse effects. A review of the literature revealed limited reports of panniculitis as an adverse effect of GA injection and even fewer describing associated skin necrosis. We report a case of GA-induced panniculitis and skin necrosis and discuss the occurrence of panniculitis, necrosis, and lipoatrophy following GA injections.
Databáze: MEDLINE