Prognostic factors in patients with penile carcinoma and inguinal lymph node metastasis.

Autor: da Costa WH; Urology Division, A.C. Camargo Cancer Center, Sao Paulo, Brazil., Rosa de Oliveira RA; Urology Division, A.C. Camargo Cancer Center, Sao Paulo, Brazil., Santana TB; Urology Division, A.C. Camargo Cancer Center, Sao Paulo, Brazil., Benigno BS; Urology Division, A.C. Camargo Cancer Center, Sao Paulo, Brazil., da Cunha IW; Pathology Division, A.C. Camargo Cancer Center, Sao Paulo, Brazil., de Cássio Zequi S; Urology Division, A.C. Camargo Cancer Center, Sao Paulo, Brazil., Guimaraes GC; Urology Division, A.C. Camargo Cancer Center, Sao Paulo, Brazil., Lopes A; Urology Division, A.C. Camargo Cancer Center, Sao Paulo, Brazil.
Jazyk: angličtina
Zdroj: International journal of urology : official journal of the Japanese Urological Association [Int J Urol] 2015 Jul; Vol. 22 (7), pp. 669-73. Date of Electronic Publication: 2015 Mar 31.
DOI: 10.1111/iju.12759
Abstrakt: Objectives: To identify prognostic factors in patients with penile carcinoma and confirmed lymph node metastasis.
Methods: Patients were selected from a historical series of patients with penile carcinoma. An experienced pathologist reviewed all cases. Information regarding the total number of lymph nodes excised, the number of positive lymph nodes and the presence of extranodal extension were used. Lymph node ratio was categorized as <0.15 and >0.15.
Results: The 5-year recurrence-free survival and disease-specific survival rates were 55.3% and 64.1%, respectively. Lymphovascular invasion, lymph node ratio and pN status influenced survival rates in univariate analysis. Lymphovascular invasion and lymph node ratio remained as independent predictors of disease-specific survival and recurrence-free survival in the multivariate analysis. A risk stratification of death and tumor recurrence was observed when patients were grouped into three categories: absence of risk factors; the presence of one risk factor; and the presence of two or more risk factors.
Conclusions: The presence of one or more of the following parameters is correlated with a significantly higher risk of death and tumor recurrence in patients with penile carcinoma and inguinal lymph node metastasis: extranodal extension, lymph node ratio >0.15 and lymphovascular invasion.
(© 2015 The Japanese Urological Association.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje