Regulation of bacterial virulence by Csr (Rsm) systems.

Autor:	Vakulskas CA; Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA., Potts AH; Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA., Babitzke P; Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA., Ahmer BM; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA Department of Microbiology, The Ohio State University, Columbus, Ohio, USA., Romeo T; Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA tromeo@ufl.edu.
Jazyk:	angličtina
Zdroj:	Microbiology and molecular biology reviews : MMBR [Microbiol Mol Biol Rev] 2015 Jun; Vol. 79 (2), pp. 193-224.
DOI:	10.1128/MMBR.00052-14
Abstrakt:	Most bacterial pathogens have the remarkable ability to flourish in the external environment and in specialized host niches. This ability requires their metabolism, physiology, and virulence factors to be responsive to changes in their surroundings. It is no surprise that the underlying genetic circuitry that supports this adaptability is multilayered and exceedingly complex. Studies over the past 2 decades have established that the CsrA/RsmA proteins, global regulators of posttranscriptional gene expression, play important roles in the expression of virulence factors of numerous proteobacterial pathogens. To accomplish these tasks, CsrA binds to the 5' untranslated and/or early coding regions of mRNAs and alters translation, mRNA turnover, and/or transcript elongation. CsrA activity is regulated by noncoding small RNAs (sRNAs) that contain multiple CsrA binding sites, which permit them to sequester multiple CsrA homodimers away from mRNA targets. Environmental cues sensed by two-component signal transduction systems and other regulatory factors govern the expression of the CsrA-binding sRNAs and, ultimately, the effects of CsrA on secretion systems, surface molecules and biofilm formation, quorum sensing, motility, pigmentation, siderophore production, and phagocytic avoidance. This review presents the workings of the Csr system, the paradigm shift that it generated for understanding posttranscriptional regulation, and its roles in virulence networks of animal and plant pathogens. (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
Databáze:	MEDLINE
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