Neuropsychological and dimensional behavioral trait profiles in Costa Rican ADHD sib pairs: Potential intermediate phenotypes for genetic studies.

Autor: Peskin VA; Department of Psychiatry, University of California, San Francisco, San Francisco, California., Ordóñez A; Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland., Mackin RS; Department of Psychiatry, University of California, San Francisco, San Francisco, California., Delucchi K; Department of Psychiatry, University of California, San Francisco, San Francisco, California., Monge S; Department of Psychiatry, Hospital CIMA, San José, Costa Rica., McGough JJ; Department of Psychiatry, University of California, Los Angeles, Los Angeles, California., Chavira DA; Department of Psychology, University of California, Los Angeles, Los Angeles, California., Berrocal M; Department of Psychiatry, Hospital CIMA, San José, Costa Rica., Cheung E; Department of Psychiatry, University of California, San Francisco, San Francisco, California., Fournier E; Department of Psychiatry, Hospital CIMA, San José, Costa Rica., Badner JA; Departments of Psychiatry and Human Genetics, University of Chicago, Chicago, Illinois., Herrera LD; Department of Psychiatry, Hospital CIMA, San José, Costa Rica., Mathews CA; Department of Psychiatry and Institute for Human Genetics, University of California, San Francisco, San Francisco, California.
Jazyk: angličtina
Zdroj: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2015 Jun; Vol. 168B (4), pp. 247-57. Date of Electronic Publication: 2015 Mar 31.
DOI: 10.1002/ajmg.b.32305
Abstrakt: Attention deficit hyperactivity disorder (ADHD) is associated with substantial functional impairment in children and in adults. Many individuals with ADHD have clear neurocognitive deficits, including problems with visual attention, processing speed, and set shifting. ADHD is etiologically complex, and although genetic factors play a role in its development, much of the genetic contribution to ADHD remains unidentified. We conducted clinical and neuropsychological assessments of 294 individuals (269 with ADHD) from 163 families (48 multigenerational families created using genealogical reconstruction, 78 affected sib pair families, and 37 trios) from the Central Valley of Costa Rica (CVCR). We used principal components analysis (PCA) to group neurocognitive and behavioral variables using the subscales of the Child Behavior Checklist (CBCL) and 15 neuropsychological measures, and created quantitative traits for heritability analyses. We identified seven cognitive and two behavioral domains. Individuals with ADHD were significantly more impaired than their unaffected siblings on most behavioral and cognitive domains. The verbal IQ domain had the highest heritability (92%), followed by auditory attention (87%), visual processing speed and problem solving (85%), and externalizing symptoms (81%). The quantitative traits identified here have high heritabilities, similar to the reported heritability of ADHD (70-90%), and may represent appropriate alternative phenotypes for genetic studies. The use of multigenerational families from a genetically isolated population may facilitate the identification of ADHD risk genes in the face of phenotypic and genetic heterogeneity.
(© 2015 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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