| Autor: |
Butler JS; a University of Alabama at Birmingham; Department of Biochemistry and Molecular Genetics ; UAB Stem Cell Institute ; Birmingham , AL USA., Napierala M |
| Jazyk: |
angličtina |
| Zdroj: |
Transcription [Transcription] 2015; Vol. 6 (2), pp. 33-6. Date of Electronic Publication: 2015 Apr 01. |
| DOI: |
10.1080/21541264.2015.1026538 |
| Abstrakt: |
Reduced expression of the mitochondrial protein Frataxin (FXN) is the underlying cause of Friedreich's ataxia. We propose a model of premature termination of FXN transcription induced by pathogenic expanded GAA repeats that links R-loop structures, antisense transcription, and heterochromatin formation as a novel mechanism of transcriptional repression in Friedreich's ataxia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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