Large-vessel stenosis in the patients with ischemic stroke in Iran: Prevalence, pattern, and risk factors.

Autor:	Borhani-Haghighi A; Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ; Departments of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran., Emami M; Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Vasaksi AS; Departments of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran., Shariat A; Departments of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran., Banihashemi MA; Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Nikseresht A; Departments of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran., Ashjazadeh N; Departments of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran., Izadi S; Departments of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran., Petramfar P; Departments of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran., Poursadegh M; Departments of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran., Jaberi AR; Departments of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran., Emami S; Department of Neurology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran., Agheli H; Neurologist, Shahidzadeh Hospital, Behbahan, Iran., Nemati R; Department of Neurology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran., Yaghoubi E; Department of Neurology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran., Abdi MH; Neurologist, Motaharri Hospital, Marvdasht, Iran., Mohammadi M; Neurologist, NIOC Hospital, Gachsaran, Iran., Jafari P; Departments of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran., Cruz-Flores S; Departments of Neurology, Texas Tech University, El Paso, USA., Edgell R; Departments of Neurology and Psychiatry , Saint Louis University, Saint Louis, USA.
Jazyk:	angličtina
Zdroj:	Journal of vascular and interventional neurology [J Vasc Interv Neurol] 2015 Feb; Vol. 8 (1), pp. 11-6.
Abstrakt:	Background: Large artery disease (LAD) is a common cause of stroke, but a little is known regarding its role in Iranian stroke patients. The current study investigates the prevalence and risk factors for cervicocephalic arterial stenosis in the patients with ischemic stroke using digital subtraction angiography (DSA). Methods: This was a prospective cross-sectional study performed in hospitals affiliated to Shiraz University of Medical Sciences from March 2011 to March 2013. Patients with ischemic stroke underwent noninvasive vascular and cardiac investigations to find the etiology of the stroke. Patients suspected of having large artery stenosis underwent DSA. The severity of the stenosis was calculated according to the North American Symptomatic Carotid Endarterectomy (NASCET) and Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Trial criteria. The presence of cigarette smoking, hyperlipidemia, hypertension, and diabetes mellitus were documented for all subjects. Results: A total of 3703 stroke patients were identified. Of them, 342 patients (62.3%, male) underwent DSA for LAD. The mean age at the time of angiography was 66.7±10.3 years. Extracranial and intracranial arteries were involved in 305 (89.2%) and 162 (47.4%), respectively. And 301 patients (88%) had anterior circulation and 128 patients (37.4%) had posterior circulation involvement. Diabetes mellitus but not age, sex, hypertension, hyperlipidemia, or smoking was significantly associated with intracranial involvement. (P = 0.002). Conclusion: It can be concluded that the distribution of the large arterial atherosclerotic disease in Iran is similar to that seen in North America and Europe. Intracranial stenosis was more prevalent in diabetic patients.
Databáze:	MEDLINE
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