High Incidence of Zidovudine Induced Anaemia in HIV Infected Patients in Southern Odisha.

Autor: Dash KR; Department of Medicine ART Center, M.K.C.G. Medical College and Hospital, Berhampur, Odisha India., Meher LK; Department of Medicine ART Center, M.K.C.G. Medical College and Hospital, Berhampur, Odisha India., Hui PK; Department of Medicine ART Center, M.K.C.G. Medical College and Hospital, Berhampur, Odisha India., Behera SK; Department of pathology ART Center, M.K.C.G. Medical College and Hospital, Berhampur, Odisha India., Nayak SN; Department of General Medicine ART Center, M.K.C.G. Medical College and Hospital, Berhampur, Odisha India.
Jazyk: angličtina
Zdroj: Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion [Indian J Hematol Blood Transfus] 2015 Jun; Vol. 31 (2), pp. 247-50. Date of Electronic Publication: 2014 Sep 28.
DOI: 10.1007/s12288-014-0426-9
Abstrakt: Zidovudine (AZT), a nucleoside reverse transcriptase inhibitor was the first breakthrough in AIDS therapy in 1990.This study was conducted with an aim to determine prevalence of AZT induced anaemia in HIV infected patients initiated on AZT containing anti retroviral therapy(ART) regimen and also to find out any risk factor for causing AZT induced anaemia. Study was carried out in ART centre, M.K.C.G, MCH, Berhampur between Jan 2009 and Dec 2011. HIV infected patients registered at ART centre were treated according to National AIDS Control Organisation (NACO) guidelines. Patients (n = 1221) with Hb >8 gm/dl were prescribed AZT based ART regimen. Patients having anaemia (<8 gm/dl) were excluded from the study. Correlation of baseline characteristics (age, sex, weight, Hb level, CD4 count, World Health Organization (WHO) clinical stage) with risk of developing anaemia was also calculated. 178 (14.6 %) patients on AZT regimen developed anaemia. Patients with low CD4 count were more prone to develop severe anaemia. Age, sex, weight, WHO clinical stage had no relation with development of anaemia. Incidence of AZT induced anaemia was very high and patients having low CD4 count were more susceptible to develop anaemia.
Databáze: MEDLINE
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