The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women.

Autor:	Mrizak I; Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia., Šerý O; Institute of Animal Physiology and Genetics, Academy of Science,Veveří 97,602 00Brno,Czech Republic., Plesnik J; Laboratory of Neurobiology and Molecular Psychiatry, Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University,Kotlářská 2,611 37Brno,Czech Republic., Arfa A; Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia., Fekih M; Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia., Bouslema A; Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia., Zaouali M; Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia., Tabka Z; Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia., Khan NA; Physiologie de la Nutrition et Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup,6, Boulevard Gabriel,Dijon21000,France.
Jazyk:	angličtina
Zdroj:	The British journal of nutrition [Br J Nutr] 2015 Apr 28; Vol. 113 (8), pp. 1330-7. Date of Electronic Publication: 2015 Mar 30.
DOI:	10.1017/S0007114515000343
Abstrakt:	Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-α (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-α gene polymorphisms.
Databáze:	MEDLINE
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