| Autor: |
Hall RM, Podger DM, Collis CM |
| Jazyk: |
angličtina |
| Zdroj: |
Mutation research [Mutat Res] 1985 Jul; Vol. 146 (1), pp. 47-53. |
| DOI: |
10.1016/0167-8817(85)90054-9 |
| Abstrakt: |
The differences between the plasmid pKM101 and its derivative pGW16, which has lost the ability to support muc-dependent phleomycin mutagenesis, while retaining other muc-dependent phenotypes, have been further investigated. Deletion derivatives which retain only 10.8 kb (approximately one third) of the pKM101 genome but retain the muc genes have been constructed from both pKM101 and pGW16. The deletion derivatives confer protection and mutagenesis-enhancing properties similar to those of their respective parents, indicating that the lesion in the mutant plasmid pGW16 lies in or close to the muc genes. Differences in the muc-dependent phenotypes of strains containing pKM101 or pGW16 suggest that the pGW16 lesion results in either differential loss of function in the muc gene products, or constitutive expression of the muc gene products. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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