DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status.

Autor: Barbosa AS; Biology Technical Team, Lauro de Souza Lima Institute, Bauru, São Paulo State Brazil ; Equipe Técnica de Biologia, Instituto Lauro de Souza Lima, Rod. Comte. João Ribeiro de Barros, km 225/226, CEP 17.034-971 Bauru, SP Brazil., de Oliveira LR; Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil., Tavares FC; Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil., de Lima CR; Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil., Diório SM; Microbiology Technical Team, Lauro de Souza Lima Institute, Bauru, São Paulo State Brazil., Calvi SA; Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil., Vilani-Moreno FR; Biology Technical Team, Lauro de Souza Lima Institute, Bauru, São Paulo State Brazil., Pereira PC; Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
Jazyk: angličtina
Zdroj: The journal of venomous animals and toxins including tropical diseases [J Venom Anim Toxins Incl Trop Dis] 2015 Mar 25; Vol. 21, pp. 10. Date of Electronic Publication: 2015 Mar 25 (Print Publication: 2015).
DOI: 10.1186/s40409-015-0006-y
Abstrakt: Background: Jorge Lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.
Methods: DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).
Results: The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.
Conclusion: These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
Databáze: MEDLINE
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